Thursday, May 31, 2012

Do I Really Need a Licensed Electrician? - IdeaMarketers.com











When you are doing home repair projects, sometimes it can be tempting just to hire a handyman or even to try to do the work yourself. After all, there are always general purpose "helpers" out there who advertise on the Internet, who put up signs or who you might hear about through word of mouth. These handymen often offer to do work at relatively low prices and you may think that this is a great deal and a good idea. In reality, however, when it comes to home improvement work, you generally get what you pay for. This means that if you want electrical work done right and done safely, you will need to hire a licensed electrician.

Why Do You Need a Licensed Electrician in Houston?

There are a number of different reasons why you need a licensed electrician in Houston, some of which are obvious and others of which may not be immediately readily apparent but which are just as important. For example, some of the reasons why you need a licensed electrician Houston include the following:

  • Only a licensed electrician can be insured and bonded.

Insured mans that the electrician is insured against any potential injury he may experience on your property (i.e. he has worker's compensation insurance) and, in many cases, that the electrician is also insured against any damage that he may cause to your home through the electrical work performed. Bonded means that the electrician has a surety bond, which is a special kind of insurance policy that protects you if the electrician doesn't do his job.

Having a licensed, insured and bonded electrician protects you from potentially being sued by an unscrupulous individual who is doing work on your home, and protects you from financial loss that might be caused by such an individual. An unlicensed person doing electrical work will be neither insured nor bonded in most cases, since he is not in compliance with the laws on licensing.

  • A licensed electrician can ensure code compliance in Houston, TX.

For certain types of installation and work performed on your home, the code requirements stipulate that a licensed electrician should perform the installation. Even when code does not require that the electrical work be performed by a licensed electrician, there are still provisions of both national and local electrical codes that must be complied with. A licensed electrician will be in the best position to ensure that you comply with all of these legal requirements.

  • A licensed electriciancan help keep your family safe

Having electrical work done by an unlicensed professional is a sure recipe for disaster. Many things can go wrong with electrical wires, ranging from shorts or overloaded circuits to serious problems that can cause a fire in your home. You do not want to take any risks with the safety of your family or the security of your property. As such, contacting only a licensed electricianis the smartest decision you can make to ensure you are making the safe choice.

Keywords: Licensed Electrician, electrician in Houston TX, electrical contractors Houston

This article has been viewed 17 time(s).

It is a violation of our terms and conditions for writers to submit material which they did not write and claim it as their own. If this article infringes on your copyrights, you MUST either call us at 706-866-2295 or send proof of infringement along with the offending article's title, URL, and writer name to

IdeaMarketers.com
Attn: Marnie Pehrson - Copyright Concern
514 Old Hickory Ln
Ringgold GA 30736 USA
If you email us or use our problem submission form, we CANNOT guarantee we'll receive your notice!

odd lamar d antoni fashion star andrew bird lizzie borden lizzie borden

Tuesday, May 29, 2012

Online Security ? Things You Must Know

'; var input_id = '#mc_embed_signup'; var f = $(input_id); if (ftypes[index]=='address'){ input_id = '#mce-'+fnames[index]+'-addr1'; f = $(input_id).parent().parent().get(0); } else if (ftypes[index]=='date'){ input_id = '#mce-'+fnames[index]+'-month'; f = $(input_id).parent().parent().get(0); } else { input_id = '#mce-'+fnames[index]; f = $().parent(input_id).get(0); } if (f){ $(f).append(html); $(input_id).focus(); } else { $('#mce-'+resp.result+'-response').show(); $('#mce-'+resp.result+'-response').html(msg); } } } catch(e){ $('#mce-'+resp.result+'-response').show(); $('#mce-'+resp.result+'-response').html(msg); } } }

vanessa bryant vanessa bryant adam lambert incendiary floyd mayweather winter solstice x factor finale

Monday, May 28, 2012

Microsoft posts Windows 8 app porting guide roundup, forgets to include BASIC

Microsoft posts Windows 8 app porting guide roundup, forgets to include BASIC

Let's say you're a developer eager to convert your apps for Windows 8 as soon as possible. Where do you start? Microsoft Developer Evangelist Jennifer Marsman is very much aware that you might be at a loss, so she has done the rather large favor of rounding up every porting guide the company has to offer in one handy place. Some of these are pure design guides, like a previously spotted iPad-to-Metro layout article, but others dig deep into converting code for the land of home tiles and charms. The focus is on porting from the web and Windows Phone 7, so we wouldn't work up hopes of bringing your high school computer class project to Metro. Still, Marsman is looking for more guides from readers; if you've developed just the technique to convert 10 PRINT "HELLO WORLD" 20 GOTO 10 into a tablet-native Windows 8 app, return the generosity and leave pointers at the source link.

Microsoft posts Windows 8 app porting guide roundup, forgets to include BASIC originally appeared on Engadget on Sun, 27 May 2012 02:01:00 EDT. Please see our terms for use of feeds.

Permalink   |  sourceMSDN Blogs  | Email this | Comments

chia seeds embers shannon brown mike rowe shld 2012 sec football schedule medifast

Housing Inspections: Why Local Is Generally Better

There?s one thing each and every home buyer or seller ought to know before even considering hiring a home building inspector: Local is always your best bet. If you are purchasing a home within Atlanta, you?ll need someone with first-hand professional experience assessing Atlanta homes. Likewise, a good inspector with prior experience inspecting houses within Pennsylvania shouldn?t assume that he or she will be completely versed in inspecting properties in Georgia. The local weather conditions play too great of a part to ignore. Without having the help of a talented, locally trained property inspector, you could wind up purchasing a home that has numerous costly long-term problems.

Environmental Concerns

Some of you may be wondering just why a home inspection is needed to begin with. To get a clear understanding, ask someone who purchased a home without the guidance from a skilled Atlanta home inspector. Imagine buying a home that?s infested with termites or that?s gradually slipping from the foundation without having ever actually suspecting that anything might have been wrong until the repair invoices start to pile up. Millions of people were evicted from their homes because of the sudden downturn in the economy and, regrettably, many of those homes sat empty for several months or years before home buyers began to make a move. With each and every passing year that nobody had been maintaining all of these properties, they became increasingly more susceptible to environmentally-mediated deterioration. If you?re not really interested in using a home building inspector, you?re taking an enormous risk with your largest investmentfinancial of your life.

It?s Simple Economics

It does not take a brain surgeon? to comprehend the simple economics at play when using a home building inspection service. Using a home building inspector might cost a few hundred dollars but, if you decide to proceed without one, you could potentially purchase a home that needs thousands and thousands of dollars for major repairs. If you feel this can?t really happen to you or your family, think again. Some of the most expensive house repairs are the ones that are extremely difficult to quickly detect with the standard general home evaluation. Since Atlanta home inspectors have the experience and specialized training to identify problems often seen in? The Atlanta, GA region, they can locate these major maintenance requirements, putting need for repairs right back on to the shoulders of the home owner or help negotiate the home at a significantly reduced sales price.

The very worst mistake a home buyer can ever do is go without the guidance of a highly experienced Atlanta home inspector. You can either take an enormous risk and hope that the home you?re purchasing is in good shape or you can employ a home inspection service? and sleep easy through the night knowing that you?re making a good investment. Let common sense reign and make sure your home becomes a pleasurable investment.

Did you enjoy this post? Why not leave a comment below and continue the conversation, or subscribe to my feed and get articles like this delivered automatically to your feed reader.

denver news frozen planet creighton new smyrna beach st. joseph walking dead puerto rico primary

Distracting Decor - Lovely Listing - Odd Finds in Real Estate Listings

ncaa tournament marchmadness mike d antoni nba trade rumors 2012 ncaa tournament schedule laurent robinson dantoni

Saturday, May 26, 2012

Successful Business Presence on Internet through Professional Web

Right now it is quite critical to take your organization on the internet and you need to get a specialist internet site developed for the same. There are lots of mistakes which designers do. Just follow these steps to stay away from them:

Target Audience: Even though beginning the site please make certain that you have your focus clear on the kind of audience you are targeting, their demographics, what are their tastes etc. All this data will assist a designer to analyse the following: Features of the Website
Focus on specific locations
Colour Combination

Sitemap: Sitemap is 1 of the most crucial elements in internet site designing. Till the time web site is not well structured it is of no use as user may possibly uncover it tough to browse the website. Often strategy the sitemap according to user requirements
Interactivity: Your site really should be interactive for the users. Earlier businesses use to have a brochure internet site but in today?s environment you require to interact with the users by means of Forums, Newsletters, Blogs and so on.
Images &amp Textual Content: Content material and images on the web site ought to be clearly visible and straightforward to read. Images used in the website really should be meaningful and professional and need to relate to the text. Fonts ought to be massive in size.? A clean website and soothing colours will entice user to go through all main portions of the website
User Friendly: Internet sites are for users and it ought to be designed in such a manner that everybody finds it simple browse

Citec styles and develops website which are user friendly. For Web Design Delhi or Web site Design Delhi get in touch with Citec nowadays.

the forgotten man mike jones just friends chronicle lance armstrong george lopez bedtime stories

Analysts play down higher-grade uranium find in Iran

[ [ [['Connery is an experienced stuntman', 2]], 'http://yhoo.it/KeQd0p', '[Slideshow: See photos taken on the way down]', ' ', '630', ' ', ' ', ], [ [['Connery is an experienced stuntman', 7]], ' http://yhoo.it/KpUoHO', '[Slideshow: Death-defying daredevils]', ' ', '630', ' ', ' ', ], [ [['know that we have confidence in', 3]], 'http://yhoo.it/LqYjAX ', '[Related: The Secret Service guide to Cartagena]', ' ', '630', ' ', ' ', ], [ [['We picked up this other dog and', 5]], 'http://yhoo.it/JUSxvi', '[Related: 8 common dog fears, how to calm them]', ' ', '630', ' ', ' ', ], [ [['accused of running a fake hepatitis B', 5]], 'http://bit.ly/JnoJYN', '[Related: Did WH share raid details with filmmakers?]', ' ', '630', ' ', ' ', ], [ [['accused of running a fake hepatitis B', 3]], 'http://bit.ly/KoKiqJ', '[Factbox: AQAP, al-Qaeda in Yemen]', ' ', '630', ' ', ' ', ], [ [['have my contacts on or glasses', 3]], 'http://abcn.ws/KTE5AZ', '[Related: Should the murder charge be dropped?]', ' ', '630', ' ', ' ', ], [ [['have made this nation great as Sarah Palin', 5]], 'http://yhoo.it/JD7nlD', '[Related: Bristol Palin reality show debuts June 19]', ' ', '630', ' ', ' ', ], [ [['have made this nation great as Sarah Palin', 1]], 'http://bit.ly/JRPFRO', '[Related: McCain adviser who vetted Palin weighs in on VP race]', ' ', '630', ' ', ' ', ], [ [['A JetBlue flight from New York to Las Vegas', 3]], 'http://yhoo.it/GV9zpj', '[Related: View photos of the JetBlue plane in Amarillo]', ' ', '630', ' ', ' ', ], [ [['the 28-year-old neighborhood watchman who shot and killed', 15]], 'http://news.yahoo.com/photos/white-house-stays-out-of-teen-s-killing-slideshow/', 'Click image to see more photos', 'http://l.yimg.com/cv/ip/ap/default/120411/martinzimmermen.jpg', '630', ' ', 'AP', ], [ [['Titanic', 7]], 'http://news.yahoo.com/titanic-anniversary/', ' ', 'http://l.yimg.com/a/p/us/news/editorial/b/4e/b4e5ad9f00b5dfeeec2226d53e173569.jpeg', '550', ' ', ' ', ], [ [['He was in shock and still strapped to his seat', 6]], 'http://news.yahoo.com/photos/navy-jet-crashes-in-virginia-slideshow/', 'Click image to see more photos', 'http://l.yimg.com/cv/ip/ap/default/120406/jet_ap.jpg', '630', ' ', 'AP', ], [ [['xxxxxxxxxxxx', 11]], 'http://news.yahoo.com/photos/russian-grannies-win-bid-to-sing-at-eurovision-1331223625-slideshow/', 'Click image to see more photos', 'http://l.yimg.com/a/p/us/news/editorial/1/56/156d92f2760dcd3e75bcd649a8b85fcf.jpeg', '500', ' ', 'AP', ] ]

[ [ [['did not go as far his colleague', 8]], '29438204', '0' ], [ [[' the 28-year-old neighborhood watchman who shot and killed', 4]], '28924649', '0' ], [ [['because I know God protects me', 14], ['Brian Snow was at a nearby credit union', 5]], '28811216', '0' ], [ [['The state news agency RIA-Novosti quoted Rosaviatsiya', 6]], '28805461', '0' ], [ [['measure all but certain to fail in the face of bipartisan', 4]], '28771014', '0' ], [ [['matter what you do in this case', 5]], '28759848', '0' ], [ [['presume laws are constitutional', 7]], '28747556', '0' ], [ [['has destroyed 15 to 25 houses', 7]], '28744868', '0' ], [ [['short answer is yes', 7]], '28746030', '0' ], [ [['opportunity to tell the real story', 7]], '28731764', '0' ], [ [['entirely respectable way to put off the searing constitutional controversy', 7]], '28723797', '0' ], [ [['point of my campaign is that big ideas matter', 9]], '28712293', '0' ], [ [['As the standoff dragged into a second day', 7]], '28687424', '0' ], [ [['French police stepped up the search', 17]], '28667224', '0' ], [ [['Seeking to elevate his candidacy back to a general', 8]], '28660934', '0' ], [ [['The tragic story of Trayvon Martin', 4]], '28647343', '0' ], [ [['Karzai will get a chance soon to express', 8]], '28630306', '0' ], [ [['powerful storms stretching', 8]], '28493546', '0' ], [ [['basic norm that death is private', 6]], '28413590', '0' ], [ [['songwriter also saw a surge in sales for her debut album', 6]], '28413590', '1', 'Watch music videos from Whitney Houston ', 'on Yahoo! Music', 'http://music.yahoo.com' ], [ [['keyword', 99999999999999999999999]], 'videoID', '1', 'overwrite-pre-description', 'overwrite-link-string', 'overwrite-link-url' ] ]

neville george lucas numerology the game new hampshire primary hue jackson alabama football

Saturday, May 19, 2012

Fitness factions: Health and fitness magazines take different ...

  • Mom battling flesh disease undergoes 5th surgery - Greenville News May 18, 2012

    The Express TribuneMom battling flesh disease undergoes 5th surgeryGreenville NewsIt was the fifth operation for Lana Kuykendall since she was first hospitalized last Friday with the rare but potentially fatal infection also known as flesh-eating bacteria. ?She remains very ill but stable,? said Dr. Bill Kelly, epidemiologist at ...South Carolina woman [?]

  • Study finds Zithromax (azithromycin) may carry higher risk of death than other ... - InjuryBoard.com May 18, 2012

    Zee NewsStudy finds Zithromax (azithromycin) may carry higher risk of death than other ...InjuryBoard.comPeople taking the popular antibiotic Zithromax (azithromycin), commonly called the ?Z-pack,? may have more than double the risk of death from cardiovascular problems than people taking other antibiotics. Vanderbilt University researchers found in a new .. [?]

  • A Stem-Cell-Based Drug Gets Approval in Canada - New York Times May 18, 2012

    A Stem-Cell-Based Drug Gets Approval in CanadaNew York TimesIn a boost for the field of regenerative medicine, a small biotechnology company has received regulatory approval in Canada for what it says is the first manufactured drug based on stem cells. The company, Osiris Therapeutics of Columbia, Md., ...Osiris Approved To Market Prochymal For Graft-Vs-Host [?]

  • Why this judge is a stoner - New York Daily News May 18, 2012

    New York Daily NewsWhy this judge is a stonerNew York Daily NewsA Brooklyn judge has given new meaning to the High Court. Supreme Court Justice Gustin Reichbach revealed Thursday he illegally smokes pot to battle the side-effects from treatment of his pancreatic cancer ? and implored state lawmakers to lighten up ...New York judge with cancer makes case for [?]

  • Coffee linked to lower risk of death - Los Angeles Times May 17, 2012

    USA TODAYCoffee linked to lower risk of deathLos Angeles TimesResearchers tracking health and coffee consumption found that coffee drinkers had a lower risk of death during the course of the study. Subjects who averaged four or five cups per day fared best, though it's not clear why. By Amina Khan, Los Angeles ...Coffee May Help Drinkers Live Longer, US [?]

  • FDA approves generic versions of blood thinner Plavix - FDA.gov May 17, 2012

    Plain DealerFDA approves generic versions of blood thinner PlavixFDA.govThe US Food and Drug Administration today approved generic versions of the blood thinning drug Plavix (clopidogrel bisulfate), which helps reduce the risk of heart attack and stroke by making it less likely that platelets in the blood will clump and ...FDA approves sales of generic versi [?]

  • Sex, age may affect athletes' concussion recovery - Reuters May 17, 2012

    Updated NewsSex, age may affect athletes' concussion recoveryReutersBy Amy Norton | NEW YORK (Reuters Health) - Female and high school athletes may need more time to recover from a concussion than their male or college counterparts, a new study finds. Researchers found that of 222 young athletes who suffered a ...Sex, age may affect concussion recoveryT [?]

  • Doubt Cast on the 'Good' in 'Good Cholesterol' - New York Times May 16, 2012

    Zee NewsDoubt Cast on the 'Good' in 'Good Cholesterol'New York TimesThe name alone sounds so encouraging: HDL, the ?good cholesterol.? The more of it in your blood, the lower your risk of heart disease. So bringing up HDL levels has got to be good for health. Or so the theory went. Now, a new study that makes use of ...Raising HDL Levels [?]

  • Breast cancer study reveals 'substantial genetic diversity' - Los Angeles Times May 16, 2012

    msnbc.comBreast cancer study reveals 'substantial genetic diversity'Los Angeles TimesA new study of the protein-coding genes in 100 breast cancer tumors revealed vast differences among the cancers and highlights how complicated the disease really is, researchers said Wednesday. ?A sobering perspective on the complexity and diversity of ...Reuters H [?]

  • This is your brain on sugar: UCLA study shows high-fructose diet sabotages ... - UC Los Angeles May 15, 2012

    The AgeThis is your brain on sugar: UCLA study shows high-fructose diet sabotages ...UC Los Angeles[Correction: Paragraph 5 of this release was changed from an earlier version to reflect that the study focused on fructose generally, not specifically on high-fructose corn syrup; that high-fructose corn syrup is not necessarily "six times sweeter" .. [?]

  • megamillions winners university of louisville louisville ky final four lotto winners mega ball winning numbers baltimore county

    Friday, May 18, 2012

    Chicago Showroom Opening - Business Review Europe

    CHICAGO, May 17, 2012 /PRNewswire-iReach/ -- Chicago Showroom Opening:
    Gateway Classic Cars announces the opening of its third location, in the Chicago market.
    The new showroom, a 45,000 sq. ft. facility, at 8451 183rd Place, Tinley Park, IL. 60487 will be showcasing classic cars, collector cars, exotic cars and trucks for sale.
    Gateway Classic Cars is a 13+ year old company, based out of St. Louis area, selling exotic and classic automobiles for private owners, collectors, and estates under consignment rules.
    The company has seen its domestic and international market share grow exponentially over the years. The company uses the latest technologies some of which including Internet and smart phone marketing and also, shipping to worldwide clients.
    For more information, please visit the company website: www.gatewayclassiccars.com or call 708-444-4488 (local) or 866-430-2345.
    The showroom will be officially open for business on Friday, June 1st, 2012.
    We will be offering Free consignments to the first 50 vehicles consigned in the Chicago showroom. We will be accepting vehicles for consignment starting May 18, 2012. Please call one of our consignment specialist at 866-430-2345 to bring your vehicle in to one of our showrooms.
    In honor of opening our Chicago showroom, we are offering free consignments in our Louisville showroom as well.? If you have an exotic, classic or collectible car, truck or motorcycle for sale, call our consignment office at 866-430-2345.

    Media Contact: Brad Kline, Gateway Classic Cars, 708-444-4488, brad@gatewayclassiccars.com

    News distributed by PR Newswire iReach: https://ireach.prnewswire.com?

    ?


    ?

    SOURCE Gateway Classic Cars

    cispa pittsburgh steelers detroit lions seattle seahawks space shuttle space shuttle new york courtney upshaw

    Video: Archbishops protest HHS Sec. Sebelius speech at Georgetown

    Sorry, Readability was unable to parse this page for content.

    new edition austerity rihanna and chris brown back together bobbi kristina brown keanu reeves pebble beach clive davis

    womens health: What Can I Learn About Womens Health And ...

    There are many different options for women and women's fitness training that are available. A lot depends on what your fitness goals are. This will also encompass how long you are giving yourself or have to get into shape.

    How much weight you are looking to lose and if you are looking just to tone up or lose weight too. But with all the options that are available for women's fitness training, it should be fairly easy to find one that will suit your personal needs.

    One option that women tend to really like for women's fitness training are aerobics classes. Your local gym or sometimes a YMCA center usually offers these. These are great for losing weight, because the fat burns off a lot easier with aerobics. However if you are looking to tone up you will need to add some weight training to the mix as well.

    Your best bet is to find a class that you can enjoy and that will work for you. A lot of the classes will offer lower impact and higher impact varieties, so choose which one would be easier for you. All in all there are a pretty wide variety of classes to choose from and you are bound to find one that will work for you and your fitness goals and needs.

    Something else that is a good option for women's fitness training is a gym. In fact there are even all women's gyms that are out there, if you prefer. This can help you with your confidence, not having to worry about men being around and such.

    This is also great because a lot of the exercises and equipment are geared specifically towards women and their needs. You may also want to choose a gym that will allow you take advantage of a personal trainer. This can help you get a better workout that is just for your needs.

    Yet another option for women's fitness training is purchasing home gym equipment. This can be a little expensive but worth it in the long run. This is mostly for those who don't have the time to get out to a gym on a regular basis. Home gyms are also a good option for those who don't feel comfortable working out in front of other people. There are many good ones out there and even some that may be geared specifically towards women and their personal workout needs.

    When it comes to women's fitness training there are definitely a few options out there to choose from. Once again it is really up to you which one will work best for your fitness goals and needs. You will also need to take into consideration your budget and time you have to spend on a workout routine. How fast you have to get into shape will also effect your decision as well. But whichever option you choose you are well on your way to a healthier and happier life.

    cpac straw poll breaking dawn part 2 breaking dawn part 2 whitney cummings msnbc i will always love you maine caucus

    Slew of rare DNA changes following population explosion may hold clues to common diseases

    ScienceDaily (May 17, 2012) ? One-letter switches in the DNA code occur much more frequently in human genomes than anticipated, but are often only found in one or a few individuals.

    The abundance of rare variations across the human genome is consistent with the population explosion of the past few thousand years, medical geneticists and evolutionary biologists report in the May 17 advanced online edition of Science.

    "This is a dramatic example of how recent human history has profoundly shaped patterns of genetic variation," said Joshua Akey, University of Washington associate professor of genome sciences and a senior author of the study. His lab studies the genetic architecture behind differences among humans (as well as among other species) and the mechanisms of evolutionary change.

    Although so-called single nucleotide variants are rare, they may influence a person's resistance or susceptibility to common diseases, like heart or lung trouble or blood problems. The rarity of each specific variation means that scientists will often need to study DNA samples from very large numbers of people to draw any genetic links to these disorders. Researchers already realize that commonly occurring gene variants have only a modest role in the complex medical conditions with the most public health repercussions.

    In this week's paper, "Evolution and Functional Impact of Rare Coding Variations from Deep Sequencing of Exomes," investigators described their study of the protein-coding sections of genomes from almost 2,440 individuals. The participants were 1,351 people of European extraction and 1,088 of African ancestry.

    The study is a first step toward understanding how rare genetic variants contribute to some of the leading chronic illness causes of death in the world. It was conducted as part of the mission of the Seattle GO at the University of Washington and the Broad GO at Harvard University and MIT, both funded by the National Institute of Health's National Heart Lung and Blood Institute Exome Sequencing Project. The exome consists of the protein-coding regions of the genome.

    The overall project encompasses a great many individuals who have distinct traits, such as heart attacks before old age, strokes, or a high body mass index, to discover the genes and molecular mechanisms behind these conditions. Low cost, rapid sequencing of whole genomes is on its way to becoming clinically feasible. The information gleaned would be more useful if statistical and experimental methods could more accurately identify gene variations that regulate biological processes and produce functionally significant proteins. Such methods would link gene variations to disease causes and provide information for preventing and treating diseases.

    The other senior author of the paper from the Exome Sequencing Project is Michael J. Bamshad, University of Washington professor of pediatrics in the Division of Genetic Medicine. Researchers from eight institutions across the nation collaborated.

    The group sequenced and compared 15,585 human protein-coding genes. They located more than a half-million single-letter DNA code variations in their sample populations. The majority of these variations arose recently in human evolutionary history and so were rare, novel, and specific either to the African or the European study populations, the researchers discovered.

    The researchers went on to pick just those single-letter variations in the DNA that might affect the functions of proteins. Alterations in protein functions are among the key ways genetic differences spin into disease traits. They estimated that a little more than 2 percent of the approximately 13,600 single nucleotide variations each person carried, on average, influenced the function of about 313 genes per genome. More than 95 percent of the single-letter code changes predicted to be functionally important were rare in the overall study population.

    How did so many rare variations affecting protein function arise in the human genetic code? The researchers suggest that this excess of rare variations is due to a combination of demographic and evolutionary forces. Both European and African populations grew exponentially beginning around 10,000 years ago, but in the past 5,000 years growth rates accelerated leading to the billions of people living today.

    The dramatic recent increase in population size has therefore profoundly influenced the spectrum of protein-coding variation present in humans. The scientists calculated the mean average of novel, single-letter code variations in their study subjects: 549 per individual overall. People of African descent had about twice the number of new variations compared to those of European descent, or 762 versus 382.

    The researchers measured the effects of natural selection on rare coding variation. To do so, they also brought in genetic details from genes highly specific to humans relative to chimps and macaques to look for what are called "selective sweeps." A selective sweep occurs when natural selection increases the frequency of a beneficial variant in a population. The beneficial variant doesn't travel alone. Nearby genetic material is swept along with it. Included among the genes the scientists culled out as affected by positive selection were those related to the sense of smell and to the use of energy.

    The researchers also learned that most of the protein-coding variations identified in their study were predicted to be harmful. Rare variation contributes not simply to each individual's uniqueness, but also to the risk for life-shortening illnesses.

    What are the implications of these findings for understanding disease and advancing personalized medicine? Before answering, the researchers pointed to present limitations in robustly identifying functional important gene variation.

    "Nevertheless," they said, "there was considerable rare genetic variation among individuals that is predicted to be functional, which could explain variability in disease risk and in drug response." The researchers would like more powerful tests to detect the effects of rare genetic variations on human health. They suggest that accounting gene-by-gene might improve research methods. They added that the population-specific nature of most of the single-letter code changes will make it challenging to replicate disease associations with a variant across the world's people.

    Share this story on Facebook, Twitter, and Google:

    Other social bookmarking and sharing tools:


    Story Source:

    The above story is reprinted from materials provided by University of Washington.

    Note: Materials may be edited for content and length. For further information, please contact the source cited above.


    Journal Reference:

    1. Jacob A. Tennessen, Abigail W. Bigham, Timothy D. O?Connor, Wenqing Fu, Eimear E. Kenny, Simon Gravel, Sean McGee, Ron Do, Xiaoming Liu, Goo Jun, Hyun Min Kang, Daniel Jordan, Suzanne M. Leal, Stacey Gabriel, Mark J. Rieder, Goncalo Abecasis, David Altshuler, Deborah A. Nickerson, Eric Boerwinkle, Shamil Sunyaev, Carlos D. Bustamante, Michael J. Bamshad, Joshua M. Akey, Broad GO, Seattle GO, and on behalf of the NHLBI Exome Sequencing Project. Evolution and Functional Impact of Rare Coding Variation from Deep Sequencing of Human Exomes. Science, 17 May 2012 [ DOI: 10.1126/science.1219240

    Note: If no author is given, the source is cited instead.

    Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

    sickle cell trait michigan football michigan football sugar bowl mild kidney failure presidential candidates celebrity wife swap

    Documents shed new light on Trayvon Martin killing

    ORLANDO, Fla. (AP) ? Trayvon Martin's autopsy shows he had marijuana in his system the night he was killed by neighborhood watch volunteer George Zimmerman, and a gunshot to his chest came from close range, according to nearly 200 pages of previously undisclosed documents released Thursday.

    At least one investigator wanted to charge Zimmerman with manslaughter but was overruled, according to the documents, which are shedding new light on a case that has raised questions about racial profiling and "stand your ground" laws. The investigator, who was on the scene after the shooting, wrote on March 13 that the confrontation should have been avoided. That report came nearly a month before Zimmerman was arrested.

    The documents, photos and video were turned over by prosecutors to defense attorneys earlier this week before they were released to the media. Included in the many witness interviews were accounts by an acquaintance of Zimmerman's who said he's racist and a co-worker who said Zimmerman bullied him and mocked him with an exaggerated Middle Eastern accent.

    The autopsy says medical examiners found THC, the psychoactive ingredient in marijuana, when they tested Martin's blood and urine. A police report shows the 17-year-old had been shot once in the chest and had been pronounced dead at the scene. The autopsy says the fatal shot was fired from no more than 18 inches away.

    Also in the package is a photo showing Zimmerman with a bloody nose on the night of the fight. A paramedic report says Zimmerman had a 1-inch laceration on his head and forehead abrasion.

    "Bleeding tenderness to his nose, and a small laceration to the back of his head. All injuries have minor bleeding," paramedic Michael Brandy wrote about Zimmerman's injuries in the report.

    Whether Zimmerman was injured in the Feb. 26 altercation with Martin has been a key question. The 28-year-old Zimmerman has claimed self-defense and said he only fired because the unarmed teenager attacked him.

    Zimmerman was not arrested for weeks because he invoked the Florida's law that does not require a person to retreat in the face of a serious threat. He was released on bail and is in hiding while he awaits trial on a second-degree murder charge. He has pleaded not guilty.

    The investigator who called for Zimmerman's arrest, Christopher Serino, told prosecutors in March that the fight could have been avoided if Zimmerman had remained in his vehicle and awaited the arrival of law enforcement. He said Zimmerman, after leaving his vehicle, could have identified himself to Martin as a concerned citizen and talked to him instead of confronting him.

    He said there is no evidence Martin was involved in any criminal activity.

    The lawyer for Martin's parents seized on the investigator's recommendation.

    "The police concluded that none of this would have happened if George Zimmerman hadn't gotten out of his car," said attorney Ben Crump. "If George Zimmerman hadn't gotten out of his car, they say it was completely avoidable. That is the headline."

    A separate report written by Serino at the crime scene says Martin had $40.15, Skittles candy, a red lighter, headphones and a photo pin in his pocket. A single 9mm shell casing was found near Martin's body.

    New witness accounts also emerged Thursday. A witness, whose name is redacted, told investigators he saw "a black male, wearing a dark colored hoodie," on top of a white or Hispanic male who was yelling for help.

    The witness, who was looking out the sliding glass door at his home about 30 feet away, said he saw the black male throwing punches "MMA (mixed martial arts) style."

    He said he told the fighters he was calling the police. He said that as he was making the call, he heard a shot. He looked outside and saw the person who had been on top laid out on the grass as if he had been shot. He said the other fighter was standing on the sidewalk, talking to another person with a flashlight.

    The case has become a national racial flashpoint because the Martin family and supporters contend Zimmerman singled Martin out because he was black.

    Two acquaintances paint an unflattering picture of Zimmerman in police interviews.

    A distraught woman tells an investigator that she stays away from Zimmerman because he's racist and because of things he's done to her in the past, but she didn't elaborate on what happened between them.

    "I don't at all know who this kid was or anything else. But I know George, and I know that he does not like black people. He would start something. He's very confrontational. It's in his blood. We'll just say that," the unidentified woman says in an audio recording.

    A man whose name was deleted from the audio told investigators that he worked with Zimmerman in 2008 for a few months. It wasn't clear which company it was.

    The man, who described his heritage as "Middle Eastern," said that when he first started many employees didn't like him. Zimmerman seized on this, the employee said, and bullied him.

    Zimmerman wanted to "get in" with the clique at work so he exaggerated a Middle Eastern accent when talking about the employee, the man said. The employee told investigators that Zimmerman made reference to terrorists and bombings when talking about him.

    "It was so immature," said the employee, who ended up writing a letter to management about Zimmerman.

    jennifer garner jennifer garner romney michigan derrick williams railgun jk rowling new book between two ferns

    Thursday, May 17, 2012

    An Interview with Carolyn Arends: Music and Writing Ministry ...

    Carolyn Arends is a speaker, songwriter and writer who has just released her tenth album. She has earned two Dove Awards and three Juno nominations and also is recognized as a West Coast Music Award Songwriter of the Year. Recently, she took time away from her busy schedule to chat with me about music and writing.

    Maranatha News: You?ll be speaking at Write! Vancouver about songwriting. Can you give us a hint about what you?ll be telling workshops participants?

    Carolyn Arends: I suspect the aggravating but undeniable secret of any writing?including song writing? is rewriting. So we?ll be looking at lyrical and musical questions you can ask of a draft of a song in a quest to take it to the next level. These questions include things like, ?Have I been abstract when I could have been concrete? Have I been passive when I could have been active? Is my melody as singable and memorable as it could be?? We?ll unpack about 20 questions as best as we can and listen to examples of really inspiring work in each of the areas we explore. They say that ?talking about music is like dancing to architecture.? It?s hard and a bit unwieldy, but that doesn?t mean it?s not worthwhile to try. And it?s never boring!

    Maranatha News: How did you start song-writing?

    Carolyn: My mom claims that as soon as I could talk, I would sing, and what I would sing wouldn?t make sense . . . but it would rhyme. I was a shy kid, and song writing was the way I found very early on to express myself. By my early teens I was writing songs to go with my pastor?s sermons. I signed my first publishing contract at 21 (writing songs for other artists) and then released the first project of my own when I was 25.

    Maranatha News: What is the hardest part about songwriting? The easiest part?

    Carolyn: I?d say the hardest part is getting a truly great idea, a lyrical ?hook? and accompanying concept that I can commit myself to and that is simultaneously unique and relatable. Once I?ve got the hook and the driving concept, the rest is relatively easy. Except, of course, when it?s not.

    Maranatha News: How did you turn from song- writing to book writing?

    Carolyn: I was a bookish kid, and if you?d asked me what I wanted to be when I grew up I would have said ?an author.? Of course, I ended up with a music career, and no complaints! But around the time my third album came out, my record company asked me to write a prose reflection on the events and ideas that had inspired the music. It turned out that I got almost as much response to the little article as I did to the album, and that led to the opportunity to write a book. Writing prose and music are very different processes, but I think they come from the same impulse to communicate?the desire to articulate and explore stuff that matters.

    Maranatha News: Now that your tenth album has released, what is your next project?

    Carolyn: I?m halfway through a Master?s Degree at Regent College, so that is my main vocational focus at the moment. My career has kind of morphed over the years from music to music-speaking-writing- teaching, and I?ve had a longing to become better equipped for those tasks. I love my studies and feel so grateful for the chance to undertake them. And in the midst of school, I?m still writing a bimonthly column (for Christianity Today), teaching music courses at PLBC, and doing a bit of concert and speaking touring.

    Carolyn Arends will be teaching two workshops on songs and songwriting during Write! Vancouver on May 26, at Tapestry on the UBC Campus. The Write! Vancouver registration deadline is this coming Friday, May 18. For more information and to register, visit the website at www.writevancouver.com.?You can also find out more about Carolyn and her books and music on her website at www.carolynarends.com.

    Bonnie Way is a stay-at-home mom who lives in B.C. with her husband and two daughters (ages 4 and 2). Bonnie conducts interviews and book reviews for Maranatha News.

    reggie mckenzie epiphany exorcism jersey shore season 5 mark driscoll unemployment rate unemployment rate

    Mike's Auto Body Donates To IVVC Automotive Program ? Aha ...

    Posted on May 15, 2012. Filed under: Business News, Press Releases, Sandwich | Tags: Aha Marketing & PR, Alethia Hummel, IL, illinois, ivvc, Mike's Auto Body, sandwich, Sandwich IL, shane skillin, stacy skillin |

    Sandwich, IL ? Mike?s Auto Body of Sandwich recently donated paint toners to the Indian Valley Vocational Center?s (IVVC) Auto Body Repair program. The toners will be used by students to help them learn how to properly mix paints to be used on cars and other vehicles. The students will also learn how to match the existing paint color on vehicles.
    ?We are glad that we could donate the paint to a great program like IVVC,? said Shane Skillin of Mike?s Auto Body. ?We?re grateful they could put the paint to good use.?
    IVVC is located in Sandwich and serves 11 area school districts with vocational skills training for high school students. Their programs include training for jobs including auto repair, building trades, computer technology, culinary arts, drafting, early childhood development, graphic design and health occupations.
    Mike?s Auto Body has been serving the Sandwich area for over 25 years. The shop offers auto body repair including painting, frame repairs, welding and panel straightening. For more information about Mike?s Auto Body, please call 815-786-8222, visit their website mikesautobody.info or ?Like? them on Facebook at facebook.com/sandwichautobody.

    Mike?s Auto Body donated paint to the IVVC Automotive Repair program.

    Pictured at Right: (Back Row, L-R) Tyler Sebby, Carlos Nunez, Merced Pulido, Edgar Olague, Erik Diaz, Sebastian Kokes, Jacob Marshall, Lucus Losic? (Front row, L-R) Jose Ramirez, Pete Kreinbrink IVVC Auto Body Repair Instructor, Shane Skillin owner of Mike?s Auto Body, Justin Whiting, Shiloh Romans

    Like this:

    Be the first to like this post.

    Make a Comment

    hanukkah gpa calculator menorah chanukah chanukah david archuleta david archuleta

    The Lies Everyone Tells on Dating Sites [Dating]

    Finding love online isn't easy. The prospect of meeting Mr. or Ms. Right seems to turn everyone into porn star used car salesmen. Luckily for you, dear dater, Vice's Brian Moylan knows exactly what everyone's lying about. More »


    loft old navy cyber monday best deals cyber monday best deals brownback brownback salvia

    Sports Radio Personality Says Tweeting Should Be Illegal

    Mike Francesa

    Mike Francesa attends the Joe Torre Safe at Home benefit honoring Mariano Rivera, in New York, on Friday, Nov. 13, 2009. (AP Photo/Peter Kramer)